1. Ibuprofen
Duration: 4–5 years
The average cost is $6.
Some customers are fortunate enough to take medications like Pfizer’s Advil infrequently, so there can be a pack sitting in the bathroom cupboard for a while. Even though it’s a good idea to avoid becoming dependent on painkillers, it’s advisable to confirm when they were purchased.

Ibuprofen, © Shutterstock, and Maddie Red
“The expiration dates are somewhat arbitrary and required by regulations, but the most significant risk is that they lose effectiveness over time rather than a safety issue,” Dr. Kim Langdon said in an Insider interview. You can still take ibuprofen, but it won’t make your aches and symptoms go away.
